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KMID : 0381120070290040473
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Genes and Genomics
2007 Volume.29 No. 4 p.473 ~ p.479
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Indications of an Adaptive Response to X-ray in Lymphocytes of Radiographers
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Kim Yang-Jee
Song Joo-Young
Choi Soo-Yong
Chung Hai-Won
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Abstract
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Lymphocytes obtained from radiographers were irradiated with high-dose X-rays and analyzed for chromosome aberrations and micronuclei to examine whether an adaptive response to ionizing radiation can be induced. The study subjects were seven male radiographers and eight male controls. The frequency of chromosome aberrations was lower
in the lymphocytes of radiographers than in those of the controls when the lymphocytes were irradiated with 1 Gy of X-rays (7.93 ± 0.78 in radiographers, 8.31 ± 0.53 in controls), whereas the frequency was higher in the lymphocytes of radiographers before the irradiation (1.36 ± 0.35 in radiographers, 0.13 ± 0.08 in controls). The same trend was observed for the frequency of micronuclei, but the difference was not statistically significant. The association with the frequencies of chromosome aberrations and micronuclei after 1 Gy of irradiation was significantly correlated in the radiographers and controls (Spearman’s correlation r = 0.5, p = 0.08). The reduced chromosome damage in the lymphocytes of the radiographers was correlated with the total cumulative dose (Spearman’s correlation, CA frequency, r = 0.7, p < 0.05; MN frequency, r = 0.5, p = 0.1). Thus, an adaptive response was observed in the radiographers, and therefore chronic occupational radiation exposure might act as an adapting dose.
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KEYWORD
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adaptive response, Chromosome aberration, Micronuclei, Radiation
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